Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
Identifieur interne : 008698 ( Main/Exploration ); précédent : 008697; suivant : 008699Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
Auteurs : Julien Chapuis [France] ; Frédéric Moisan [France] ; Georges Mellick [Australie] ; Alexis Elbaz [France] ; Peter Silburn [Australie] ; Florence Pasquier [France] ; Didier Hannequin [France] ; Corinne Lendon [Australie] ; Dominique Campion [France] ; Philippe Amouyel [France] ; Jean-Charles Lambert [France]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2008-09-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Association, Génétique.
English descriptors
- KwdEn :
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD case–control studies (n = 3176) and two independent PD case–control studies (n = 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.
Url:
DOI: 10.1093/hmg/ddn183
Affiliations:
- Australie, France
- Haute-Normandie, Hauts-de-France, Nord-Pas-de-Calais, Région Normandie, Île-de-France
- Lille, Paris, Rouen
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Le document en format XML
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type="ISSN">0964-6906</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Association</term><term>Gene</term><term>Genetics</term><term>Parkinson disease</term><term>Risk</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association</term><term>Démence d'Alzheimer</term><term>Gène</term><term>Génétique</term><term>Maladie de Parkinson</term><term>Risque</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Alzheimer's disease (AD) and Parkinson's disease (PD), the two most common neurodegenerative disorders in the elderly, have been hypothesized to share genetic determinants. Recently, Li et al. proposed that a variant in the NEDD9 gene may be one of these common genetic factors. We attempted to confirm this initial observation by conducting an equivalent analysis in terms of pathologies and sample size. We genotyped the NEDD9 rs760678 SNP in three independent AD case–control studies (n = 3176) and two independent PD case–control studies (n = 1855). However, we failed to detect an association of this SNP with the risk of developing AD or PD, in any of these populations. In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Haute-Normandie</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li><li>Région Normandie</li><li>Île-de-France</li></region><settlement><li>Lille</li><li>Paris</li><li>Rouen</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Chapuis, Julien" sort="Chapuis, Julien" uniqKey="Chapuis J" first="Julien" last="Chapuis">Julien Chapuis</name></region><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name></country><country name="Australie"><noRegion><name sortKey="Mellick, Georges" sort="Mellick, Georges" uniqKey="Mellick G" first="Georges" last="Mellick">Georges Mellick</name></noRegion><name sortKey="Lendon, Corinne" sort="Lendon, Corinne" uniqKey="Lendon C" first="Corinne" last="Lendon">Corinne Lendon</name><name sortKey="Silburn, Peter" sort="Silburn, Peter" uniqKey="Silburn P" first="Peter" last="Silburn">Peter Silburn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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